Large-scale prokaryotic gene prediction and comparison to genome annotation
نویسندگان
چکیده
منابع مشابه
Large-scale prokaryotic gene prediction and comparison to genome annotation
MOTIVATION Prokaryotic genomes are sequenced and annotated at an increasing rate. The methods of annotation vary between sequencing groups. It makes genome comparison difficult and may lead to propagation of errors when questionable assignments are adapted from one genome to another. Genome comparison either on a large or small scale would be facilitated by using a single standard for annotatio...
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The process of annotating prokaryotic genomes includes prediction of protein-coding genes, as well as other functional genome units such as structural RNAs, tRNAs, small RNAs, pseudogenes, control regions, direct and inverted repeats, insertion sequences, transposons, and other mobile elements. Bacterial and archaeal genomes have the considerable advantage of usually lacking introns, which subs...
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Recent technological advances have opened unprecedented opportunities for large-scale sequencing and analysis of populations of pathogenic species in disease outbreaks, as well as for large-scale diversity studies aimed at expanding our knowledge across the whole domain of prokaryotes. To meet the challenge of timely interpretation of structure, function and meaning of this vast genetic informa...
متن کاملThe Prokaryotic Genome Annotation Pipeline
Contact: [email protected] NCBI Handout Series | Prokaryotic Genome Annotation Pipeline | Last Updated on May 25, 2017 Introduction Genome annotation is a complex process that includes prediction of protein-coding genes and other functional genome units, i.e., structural RNAs, tRNAs, small RNAs, pseudogenes, control regions, direct and inverted repeats, insertion sequences, as well as trans...
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UNLABELLED The multiplex capability and high yield of current day DNA-sequencing instruments has made bacterial whole genome sequencing a routine affair. The subsequent de novo assembly of reads into contigs has been well addressed. The final step of annotating all relevant genomic features on those contigs can be achieved slowly using existing web- and email-based systems, but these are not ap...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2005
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bti701